Gloucester number eight Ben Morgan is included in the England squad for the autumn internationals, but there is no place for team-mate Danny Cipriani.
Morgan, 29, last featured for England in 2015, but earns a place amid a back-row injury crisis.
Bath’s uncapped wing Joe Cokanasiga is one of eight uncapped players in the 36-man squad.
Dylan Hartley and Owen Farrell, who led the team this summer in Hartley’s absence, are named as co-captains.
Bath’s 21-year-old Zach Mercer, who led England Under-20s to their age-grade World Championship final in 2017, is the only other number eight in the squad alongside Morgan.
Wing Chris Ashton, who returned from France to play for Sale this season, is also included.
England face South Africa on 3 November before matches against world champions New Zealand, Japan and Australia on successive weekends.
“We can only control what we can control and injuries have happened,” said coach Eddie Jones.
“It gives an opportunity for some good new players to play some important Tests for England, while players who have been in the squad before will have to take on more responsibility.”
England have been hit by a raft of injuries with number eight Billy Vunipola, prop Mako Vunipola, flanker Chris Robshaw and second row Joe Launchbury all on the sidelines.
Nathan Hughes, who would likely have stepped in to replace Billy Vunipola at number eight, is serving a six-week ban for punching an opponent, while prop Joe Marler, 28, unexpectedly retired from international rugby last month.
In the backs, Bath pair Jonathan Joseph and Anthony Watson are both ruled out with injuries while fellow British and Irish Lion Ben Te’o is only expected to make his comeback from a thigh injury this weekend.
After winning their first 17 Tests under coach Eddie Jones, England have lost six out of their past seven games, finishing fifth in the Six Nations and losing their summer Test series against South Africa.
RFU chief executive Steve Brown admitted in July that the team’s form was “disappointing” but backed Jones to lead England to the World Cup in September 2019.
England, who failed to get out of their pool at the 2015 tournament, have been drawn alongside France, Argentina, the United States and Tonga in Japan.
England squad for the autumn internationals
Tom Curry (Sale Sharks), Charlie Ewels (Bath Rugby), Jamie George (Saracens), Dylan Hartley (Northampton Saints) co-captain, Alec Hepburn (Exeter Chiefs), Ted Hill (Worcester Warriors)*, Maro Itoje (Saracens), George Kruis (Saracens), Courtney Lawes (Northampton Saints), Zach Mercer (Bath Rugby), Ben Moon (Exeter Chiefs), Ben Morgan (Gloucester Rugby), Michael Rhodes (Saracens), Nick Schonert (Worcester Warriors), Brad Shields (Wasps), Kyle Sinckler (Harlequins), Elliott Stooke (Bath Rugby), Sam Underhill (Bath Rugby), Harry Williams (Exeter Chiefs), Mark Wilson (Newcastle Falcons)
Chris Ashton (Sale Sharks), Mike Brown (Harlequins), Danny Care (Harlequins), Joe Cokanasiga (Bath Rugby), Elliot Daly (Wasps), Nathan Earle (Harlequins), Owen Farrell (Saracens) co-captain, George Ford (Leicester Tigers), Alex Lozowski (Saracens), Jonny May (Leicester Tigers), Jack Nowell (Exeter Chiefs), Henry Slade (Exeter Chiefs), Ben Te’o (Worcester Warriors), Manu Tuilagi (Leicester Tigers), Richard Wigglesworth (Saracens), Ben Youngs (Leicester Tigers)